Overview

Cephalogics, LLC is working to develop a novel neuromonitoring device. This technology will represent a significant gain in terms of cost and ease of use over current neuromonitoring technologies that are not continuous and require transport or are invasive and focal. The Cephalogics system will provide a noninvasive continuous bedside neuromonitoring solution that will display data and imaging from multiple areas of the brain. A primary area of interest for Cephalogics is developing the technology for neurocritical care monitoring to assess the effects of treatment on the brain.

Cephalogics’ technology is being developed as a result of a partnership between Allied Minds and Dr. Joseph P. Culver at Washington University in St. Louis. Dr. Culver is an Assistant Professor in the Department of Radiology.

Technology

Cephalogics is developing an advanced neuromonitoring system to display cortical hemodynamic data and imaging. The core technology is termed diffuse optical tomography (DOT) and utilizes high-density, diffuse optical arrays to generate overlapping measurements. Signal processing algorithms have been developed to interpret the data provided by this dense spatial sampling technique.

With unique capabilities as a functional neuroimaging method, DOT complements and expands upon other more established modalities. In contrast to positron emission tomography (PET) and magnetic resonance imaging (MRI) – both of which require transport, use large, room-size scanners and require the subject to remain inside a tube for an extended period – DOT is a continuous bedside monitor.

Future Goals

We are in the process of advancing the technology to meet the user requirements in environments like neurocritical care, surgery, and neonatology. After completing product development, we will work with our clinical collaborators to research the utility of this device in the clinical setting.